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sparsentan will lessen the level or impact of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and lowers efficacy linked to these substrates.The novel wake-advertising agent modafinil has long been in use for your cure of several slumber Ailments